Inhibition of PD-1/PD-L1 showed durable efficacy in phase Ⅰ studies, and phase Ⅲ evaluation is warranted. Therapeutic strategy to concurrently inhibit multiple tyrosine kinases is a reasonable option, however, lapatinib needs to be further evaluated to identify good responders. Regorafenib has shown promising effectiveness in prolonging progression-free survival in a phase Ⅱ study. In this topic highlight, we review the biologic roles and outcomes of clinical studies targeting these signaling pathways.
非小细胞肺癌(NSCLC)占肺癌总数的80%~85%,且大部分就诊时已属晚期~([1])。目前对于晚期NSCLC,除全身化学治疗外,根据分子标记物的不同,进行有针对性的个体化分子靶向治疗占据重要地位。克唑替尼作为NSCLC中最新的靶向酪氨酸激酶之一,2013年已在国内上市。该药用于治疗间变性淋巴瘤激酶(ALK)基因重排阳性的局部晚期或转移性NSCLC。既往研究表明,该药物主要不良反应包括视觉障碍、肝功能异常、皮疹、腹泻等~([2]),但由
目的探讨microRNA-196a2基因多态性(rs1614913)与中国人群肺癌发病相关性。方法应用高分辨率溶解曲线(high
无 http://www.selleckchem.cn/products/Gefitinib.html resolution melting,HRM)分析技术对32例肺癌患者、27例肺部良性肿瘤患者及84例健康个体的microRNA-196a2基因多态性进行分析,并采用聚合酶链反应-限制性片段长度多态性(PCR-restriction fragment length polymorphism,PCRRFLP)技术加以佐证。结果 micro-196a2在各组基因型分布均达到Hardy-Weinberg平衡。肺癌组C等位基因的分布频率高于对照组(P=0.0016),OR=2.592(95%CI1.424~4.716),说明C等位基因增加肺癌患病风险。结论
MicroRNA-196a2T/C(rs1614913)多态性增加肺癌的发病风险。MicroRNA-196a2基因多态性rs1614913可能是肺癌的一种有效的遗传标记物。
目的观察重组人血管内皮抑素(恩度)对中晚期非小细胞肺癌的疗效。方法回顾性分析2008年5月~2011年5月间我院65例中晚期非小细胞肺癌临床资料。其中GP组32例接受GP方案化疗[(吉西他滨1000 mg/m~2,d1+d8)、顺铂(20 mg/m~2,d1~5)];联合组33例在GP方案基础上同时加用恩度(15 mg/d,d1~14)。两组患者均接受4~6周期化疗。观察比较两组患者近期疗效、功能状态评分、不良反应及生存率。结果联合组近期疗效明显优于GP组(P=0.0390),联合组总有效率明显优于GP组(P=0.0467);两组在不良反应方面无明显差异,均无化疗相关性死亡病例发生;化疗结束3个月后联合组KPS评分明显优于GP组[(91.52±11.25)vs(85.74±10.97),(P=0.0401)];GP组3年生存率21.88%,联合组3年生存率27.27%,联合组明显高于GP组(P=0.0425)。结论恩度联合GP方案化疗治疗晚期非小细胞肺癌可明显提高临床疗效,提高生存率,且耐受性好,值得临床推广应用。
Objective: 点击此处 To explore the role of the abnormal expression of miRNAs in
the development process of non-small cell lung cancer and the feasibility of ultrasound microbubble-mediated gene therapy after transfecting antisense miRNA-224 and miRNA-122 a plasmids into nonsmall cell lung cancer A549 cells. Methods: Antisense miRNA-224 and miRNA-122 a plasmids were transfected into non-small cell lung cancer A549 cells on the optimal ultrasound microbubble mediated condition. We set up a control group. The cell proliferation activity, apoptosis, invasion ability were detected by MTT assay, Annexin V-PE, Transwell invasion experiment and colony formation assay, respectively. Results: The expression of mi RNA-224 decreased and the expression of miRNA-122 a rose after the plasmids of target genes were transfected into non-small cell lung cancer A549 cells, and there were significant differences when compared with those of the control group(P< 0.05). Besides, the inhibition of miRNA-122 a group was the most significant and there was statistically significant difference as compared with miRNA-224 group(t =-4.694, P = 0.009).