Such metastases are referred to as oligometastases. Local therapy, such as surgical resection and radiotherapy, has been suggested to be the first-line treatment of choice foroligometastatic recurrence; and(3) While locoregional recurrence is likely to cause troublesome symptoms, it is a potentially limited

disease. Therefore, providing local control is important, and radiation is usually beneficial for treating local recurrence. In order to obtain better control of the disease and provide treatment with curative intent in patients with limited disease, the administration of concurrent platinum-based chemoradiotherapy is recommended according to the results of originally nonresectable stage ⅢA and ⅢB disease.
目的探讨儿童炎症性肌纤维母细胞性肿瘤(IMT)的临床特点、病理组织学特征及鉴别诊断。方法回顾性分析2006~2014年15例儿童IMT的临床资料,进行组织形态学分析及免疫表型检测。结果15例IMT术后随访时间为3~60个月,其中10例无瘤生存,3例术后半年到1年内复发,1例发生恶变。1例失访。免疫组化结果:梭形细胞胞质内波形蛋白、平滑肌肌动蛋白、肌特异性肌动蛋白、结蛋白阳性率分别为100%(15/15)、87%(13/15)、80%(12/15)、47%(7/15);间变型淋巴瘤激酶阳性率为40%(6/15);Ki-67阳性超过15%1例,Ki-67阳性10%2例,Ki-67阳性小于5%12例。CD117、S-100、CD34(内皮细胞标记)、肌调节蛋白、肌浆蛋白、肌红蛋白均为阴性。结论儿童IMT是具有恶变倾向的间叶性肿瘤,具有一定的复发率。手术彻底切除仍为目前首选的治疗方法,放疗和化疗的作用有待进一步探讨。
Head

selleck产品 KRX 0401 and neck squamous cell carcinoma is the sixth most common cancer in the world with approximately650000 new cases diagnosed annually.Next-generation molecular techniques and results from phase 2 of the Cancer Genome Atlas becoming available have drastically improved our current knowledge on the genetics basis of head and neck squamous cell carcinoma.New insights and new perspectives on the mutational landscape implicated in head and neck squamous cell carcinoma provide improved tools for prognostication.More importantly,depend on the patient’s tumor

subtypes and prognosis,deescalated or more aggressive therapy maybe chosen to achieve greater potency while minimizing the toxicity of therapy.This paper aims to review our current 也许 knowledge on the genetic mutations and altered molecular pathways in head and neck squamous cell carcinoma.Some of the most common mutations in head and neck squamous cell carcinoma reported by the cancer genome atlas including TP53,NOTCH1,Rb,CDKN2 A,Ras,PIK3 CA and EGFR are described here.Additionally,the emerging role of epigenetics and the role of human papilloma virus in head and neck squamous cell carcinoma are also discussed in this review.The molecular pathways,clinical applications,actionable molecular targets and potential therapeutic strategies are highlighted and discussed in details.
目的观察吉西他滨或长春瑞滨联合顺铂一线治疗晚期非小细胞肺癌(NSCLC)的近期疗效及毒副反应。方法回顾性分析我院自2011年8月1日~2014年1月31日期间应用吉西他滨或长春瑞滨联合顺铂一线治疗晚期转移性NSCLC近期疗效及毒副反应。结果共计72例患者纳入统计,34例接受吉西他滨联合顺铂化疗(GP组),38例接受长春瑞滨联合顺铂化疗(NP组),两组患者间一般情况的差异均无统计学意义(P>0.05)。GP方案一线治疗晚期转移性NSCLC有效率略高于NP方案(GP组38.24%比NP组34.21%,χ2=0.126,P=0.723)。两组主要毒副反应为化疗后骨髓抑制(GP组44.12%比NP组39.47%,χ2=0.159,P=0.690)、恶心呕吐(GP组20.59%比NP组23.68%,χ2=0.002,P=0.